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《医学前沿(英文)》 2013年 第7卷 第2期 页码 255-263 doi: 10.1007/s11684-012-0227-1
The efficacy of ursodeoxycholic acid (UDCA) on long-term outcome of primary biliary cirrhosis (PBC) has been less documented in Chinese cohort. We aimed to assess the therapeutic effect of UDCA on Chinese patients with PBC. In the present study, 67 patients with PBC were treated with UDCA (13–15 mg?kg-1?day-1) and followed up for 2 years to evaluate the changes of symptoms, laboratory values and histological features. As the results indicated, fatigue and pruritus were obviously improved by UDCA, particularly in patients with mild or moderate symptoms. The alkaline phosphatase and γ-glutamyl transpetidase levels significantly declined at year 2 comparing to baseline values, with the most profound effects achieved in patients at stage 2. The levels of alanine aminotransferase and aspartate aminotransferase significantly decreased whereas serum bilirubin and immunoglobulin M levels exhibited no significant change. Histological feature was stable in patients at stages 1–2 but still progressed in patients at stages 3–4. The biochemical response of patients at stage 2 was much better than that of patients at stages 3–4. These data suggest that, when treated in earlier stage, patients in long-term administration of UDCA can gain favorable results not only on symptoms and biochemical responses but also on histology. It is also indicated that later histological stage, bad biochemical response and severe symptom may be indicators of poor prognosis for UDCA therapy.
关键词: primary biliary cirrhosis ursodeoxycholic acid Chinese biochemical response therapeutic efficacy
Laparoscopic hepato-biliary-pancreatic surgery: present practices and prospects
Yongjun Chen, Renyi Qin, Xiaoping Chen
《医学前沿(英文)》 2011年 第5卷 第3期 页码 235-238 doi: 10.1007/s11684-011-0156-4
Correlation between viral load and liver cirrhosis in chronic hepatitis B patients
Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 271-276 doi: 10.1007/s11684-009-0054-1
Pei-Tu REN BM, Bao-Chun LU MM, Zhi-Liang CHEN MM, Hong FU MM,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 77-81 doi: 10.1007/s11684-010-0005-x
关键词: biliary disease cardiopulmonary complication stair-climbing test
ZHU Lidong, CHEN Xiaoping
《医学前沿(英文)》 2007年 第1卷 第4期 页码 364-368 doi: 10.1007/s11684-007-0070-y
Reducing biliary complications in adult-to-adult living donor liver transplantation using right lobe
YAN Lunan, WEN Tianfu, WANG Wentao, YANG Jiayin, XU Mingqing, CHEN Zheyu, WU Hong
《医学前沿(英文)》 2008年 第2卷 第2期 页码 130-133 doi: 10.1007/s11684-008-0024-z
Evaluation of power regeneration in primary suspension for a railway vehicle
Ruichen WANG, Zhiwei WANG
《机械工程前沿(英文)》 2020年 第15卷 第2期 页码 265-278 doi: 10.1007/s11465-019-0571-9
关键词: railway vehicle primary damper power regeneration ride comfort running safety
Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats
LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong
《医学前沿(英文)》 2008年 第2卷 第1期 页码 39-44 doi: 10.1007/s11684-008-0008-z
关键词: Decoction intervention serine/threonine-protein underwent Decoction glutathione peroxidase
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 63-71 doi: 10.1007/s11684-014-0342-2
Cryoablation is a less prevalent percutaneous ablative therapy for hepatocellular carcinoma (HCC), and current evidence about its usefulness is limited. We report our experience in treating 1595 HCC cases with percutaneous cryoablation to give a comprehensive profile about the effectiveness, safety and long-term outcome of this therapy. From January 2003 to December 2013, 1595 patients with 2313 HCC nodules were ablated with 2945 cryoablation sessions in our center. Complete ablation was achieved in 1294 patients for 1893 nodules with a mean diameter of 3.4±2.2 cm. The complete ablation rate was 81.2%, 99.4%, 94.4%, and 45.6% in all tumors, tumors<3 cm, tumors<5 cm, and tumors>5 cm, respectively. Major complications were observed after 80 (3.4%) of the 2945 cryoablations and minor complications were observed after 330 cryoablations with no treatment-related deaths. After a median follow-up of 33.4 months, 937 patients developed different types of recurrence. The 5- and 10-year overall survival was 25.7% and 9.2%, respectively. Cryoablation showed reliable safety and efficacy and should be considered as a promising technique, particularly when a large zone of ablation is required.
关键词: hepatocellular carcinoma percutaneous cryoablation efficacy safety
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
《医学前沿(英文)》 页码 957-971 doi: 10.1007/s11684-023-0988-8
关键词: DNAH10 mice motile cilia mutation primary ciliary dyskinesia
Approach for natural gas to be a primary energy source in China
Weihe HUANG, Jindian CHEN, Chuan FU, Yan HUANG
《工程管理前沿(英文)》 2019年 第6卷 第4期 页码 467-476 doi: 10.1007/s42524-019-0068-6
关键词: natural gas energy revolution primary energy utilization areas approaching means
Assessment of liver volume variation to evaluate liver function
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《医学前沿(英文)》 2012年 第6卷 第4期 页码 421-427 doi: 10.1007/s11684-012-0223-5
In order to assess the value of liver volumetry in cirrhosis and acute liver failure (ALF) patients, we explored the correlation between hepatic volume and severity of the hepatic diseases. The clinical data of 48 cirrhosis patients with 60 normal controls and 39 ALF patients were collected. Computed tomography-derived liver volume (CTLV) and body surface area (BSA) of normal controls were calculated to get a regression formula for standard liver volume (SLV) and BSA. Then CTLV and SLV of all patients were calculated and grouped by Child-Turcotte-Pugh classification for cirrhosis patients and assigned according to prognosis of ALF patients for further comparison. It turned out that the mean liver volume of the control group was 1 058±337 cm3. SLV was correlated with BSA according to the regression formula. The hepatic volume of cirrhosis patients in Child A, B level was not reduced, but in Child C level it was significantly reduced with the lowest liver volume index (CTLV/SLV). Likewise, in the death group of ALF patients, the volume index was significantly lower than that of the survival group. Based on volumetric study, we proposed an ROC (receiver operating characteristic) analysis to predict the prognosis of ALF patients that CTLV/SLV<83.9% indicates a poor prognosis. In conclusion, the CTLV/SLV ratio, which reflects liver volume variations, correlates well with the liver function and progression of cirrhosis and ALF. It is also a very useful marker for predicting the prognosis of ALF.
关键词: liver volume variation cirrhosis acute liver failure (ALF)
Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 191-202 doi: 10.1007/s11684-017-0512-0
Primary hepatic carcinoma (PHC) is a common malignant tumor in China. Cancer is comprehensively treated with various therapeutic regimes, including traditional Chinese medicine (TCM). TCM has been widely used to improve the quality of life, delay the time of cancer progression, and prolong the median survival time. This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma. A comprehensive literature search was conducted in six databases, including CNKI, VIP, Wan-Fang Database, CBM, PubMed, and Cochrane library. A total of 44 randomized controlled trials (RCTs) involving 3429 participants suffering from PHC were selected. Meta-analysis results indicated that the overall effect of TCM and Western integrative treatment on PHC was higher than that of Western intervention alone, which can postpone tumor recurrence and metastasis and prolong the overall survival time of patients with PHC. Although the obtained evidence remained weak because of the poor methodological quality of the included studies, this review provided relevant data supporting the efficacy and safety of TCM combined with Western therapies. In future research, individual RCT studies should incorporate accepted standards for trial design and reporting, proper outcome indicators according to international standards, blinding in allocation concealment, and valid follow-up periods.
关键词: traditional Chinese medicine primary hepatic carcinoma meta-analysis
《环境科学与工程前沿(英文)》 2022年 第16卷 第4期 doi: 10.1007/s11783-021-1474-7
• PA layer properties tune the primary nanochannels in MIL-101(Cr) TFN NF membranes.
关键词: Porous metal organic framework Thin-film nanocomposite membrane Primary selective nanochannels Nanofiltration Endocrine disrupting compounds
Primary hypertrophic osteoarthropathy: an update
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《医学前沿(英文)》 2013年 第7卷 第1期 页码 60-64 doi: 10.1007/s11684-013-0246-6
Digital clubbing, which has been recognized as a sign of systemic disease, is one of the most ancient diseases. However, the pathogenesis of clubbing and hypertrophic osteoarthropathy has hitherto been poorly understood. The study of a clinically indistinguishable idiopathic form (primary hypertrophic osteoarthropathy, PHO) provides an opportunity to understand the pathogenesis of hypertrophic osteoarthropathy. Current advances in the study of PHO are discussed. The impaired metabolism of prostaglandin E2 (PGE2) plays a central role in its pathogenesis.
关键词: digital clubbing primary hypertrophic osteoarthropathy prostaglandin E2 (PGE2)
标题 作者 时间 类型 操作
Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliarycirrhosis: a 2-year follow-up study
null
期刊论文
Laparoscopic hepato-biliary-pancreatic surgery: present practices and prospects
Yongjun Chen, Renyi Qin, Xiaoping Chen
期刊论文
Correlation between viral load and liver cirrhosis in chronic hepatitis B patients
Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,
期刊论文
stair-climbing test in predicting postoperative cardiopulmonary complications in elderly patients with biliary
Pei-Tu REN BM, Bao-Chun LU MM, Zhi-Liang CHEN MM, Hong FU MM,
期刊论文
TNF-α in patients with advanced malignant obstructive jaundice treated by percutaneous transhepatic biliary
ZHU Lidong, CHEN Xiaoping
期刊论文
Reducing biliary complications in adult-to-adult living donor liver transplantation using right lobe
YAN Lunan, WEN Tianfu, WANG Wentao, YANG Jiayin, XU Mingqing, CHEN Zheyu, WU Hong
期刊论文
Evaluation of power regeneration in primary suspension for a railway vehicle
Ruichen WANG, Zhiwei WANG
期刊论文
Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats
LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong
期刊论文
Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated
null
期刊论文
Approach for natural gas to be a primary energy source in China
Weihe HUANG, Jindian CHEN, Chuan FU, Yan HUANG
期刊论文
Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a
null
期刊论文
Tuning the primary selective nanochannels of MOF thin-film nanocomposite nanofiltration membranes for
期刊论文